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Toluene → N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(2-methylpentanoyl)thiourea

HRID 721953
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HRID 721953 반응식
[CH3:1][CH:2]([CH2:8][CH2:9][CH3:10])[C:3]([N:5]=[C:6]=[S:7])=[O:4].[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[O:23][CH3:24])[N:19]=[CH:18][N:17]=[C:16]2[O:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1.C1(C)C=CC=CC=1>C(O)C>[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][C:22]=1[O:23][CH3:24])[N:19]=[CH:18][N:17]=[C:16]2[O:25][C:26]1[CH:32]=[CH:31][C:29]([NH:30][C:6]([NH:5][C:3](=[O:4])[CH:2]([CH3:1])[CH2:8][CH2:9][CH3:10])=[S:7])=[CH:28][CH:27]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1140TolueneHCID 116163634-(6,7-Dimethoxyquinazolin-4-yloxy)anilineHCID 218904792-Methylpentanoyl isothiocyanate

생성물 1

HCID 21890971N-{4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(2-methylpentanoyl)thiourea수율 57%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

2-Methylpentanoyl isothiocyanate prepared according to the method 2 was dissolved in ethanol (1 ml) to prepare a solution. 4-[(6,7-Dimethoxy-4-quinazolinyl)oxy]aniline (50 mg), toluene (5 ml), and ethanol (1 ml) were added to the solution, and the mixture was stirred at room temperature for 16 hr. The reaction solution was concentrated, and the residue was purified by chromatography on silica gel using chloroform/acetone for development to give the title compound (44 mg, yield 57%).

후처리

  1. customto prepare a solution
  2. concentrationThe reaction solution was concentrated
  3. customthe residue was purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-b783f78d4e1d4f4988e227eefa92166d
출처 데이터셋
uspto-grants-2006_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07135466B2

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