Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Amino-4'-chlorobiphenyl-3-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-Chlorophenylboronic acid | HCID 74299 | — |
| 반응물 | Methyl 2-amino-5-bromobenzoate | HCID 736224 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Sodium Carbonate | HCID 10340 | — |
| 생성물 | 4-Amino-4'-chlorobiphenyl-3-carboxylic acid methyl ester | HCID 68979692 | — |
반응 단계
A solution of 2-amino-5-bromobenzoic acid methyl ester (460.1 mg) in degassed toluene was mixed with tetrakis(triphenylphosphine)palladium (0) (62.4 mg) and stirred at room temperature for 10 min. Then 4-chlorophenylboronic acid (344 mg) in ethanol (0.76 mL) and 2 M sodium carbonate solution (1.34 mL) were added, and the reaction mixture was heated at 100° C. overnight. The reaction was then mixed with ethyl acetate and water. The aqueous phase was extracted several times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated. The crude product was purified by preparative HPLC. The product with the molecular weight of 261.71 (C14H12ClNO2) was obtained in this way; MS (ESI): 262 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828991B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d0fe431e8771484abd3fc46fec128397 |
| 출처 메모 | uspto-grants-2014_09 |