Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Chloro-2-pyridinecarbonitrile | HCID 693342 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Chloropyridine-2-carboximidamide hydrochloride | HCID 21882000 | — |
반응 단계
6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07138363B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-528d91a0dcf84f06a23884b2a2156c5a |
| 출처 메모 | uspto-grants-2006_11 |