Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride

HRID 721990

반응식

HRID 721990 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.C[O-].[Na+].[Cl-].[NH4+:14]>CO>[ClH:1].[C:8]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)(=[NH:14])[NH2:9]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 6933424-Chloro-2-pyridinecarbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 218820004-Chloropyridine-2-carboximidamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

후처리

  1. temperaturerefluxing
  2. customThe volatile components are then removed in vacuo

출처 및 근거

ORD 기록
ord-528d91a0dcf84f06a23884b2a2156c5a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138363B2

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