Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Atorvastatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Atorvastatin tert-butyl ester | HCID 11238911 | — |
| 반응물 | KOH MeOH Water | HCID 86591755 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Atorvastatin | HCID 60823 | — |
반응 단계
The crude (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid, t-butyl ester (VI-A) was converted to the acid using an excess of KOH/MeOH/Water, followed by lactonization in toluene with catalytic HCl. Chiral HPLC analysis (ChiralCel OF; 1 ml/min; 60° C.; 254 nm; 20% IPA:Hexanes) tR(3R,5R)=26.97 min./tR(3S,5S)=33.8 min. tR(3R,5S)=38.1 min./tR(3S,5R)=61.0 min.) indicated an enantiomeric excess of the syn isomer of 85%, favoring the (R,R) configuration.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084282B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-28f25661c0c749d289fe2eb55676d218 |
| 출처 메모 | uspto-grants-2006_08 |