Potassium Carbonate → 6-Bromo-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine

HRID 722112노트

반응식

HRID 722112 반응식
Br[CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([CH3:11])=[CH:5][N:4]=1.[Br:12][C:13]1[N:21]=[C:20]([NH2:22])[N:19]=[C:18]2[C:14]=1[N:15]=[CH:16][NH:17]2.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:12][C:13]1[N:21]=[C:20]([NH2:22])[N:19]=[C:18]2[C:14]=1[N:15]=[CH:16][N:17]2[CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([CH3:11])=[CH:5][N:4]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 167350512-Bromomethyl-3,4,5-trimethyl-pyridineHCID 1785082656-bromo-1H-purin-2-amine

생성물 1

HCID 218830036-Bromo-9-(3,4,5-trimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound was obtained by reacting 2-bromomethyl-3,4,5-trimethyl-pyridine (see example 117) with 6-bromo-9H-purin-2-ylamine in the presence of K2CO3 in DMF for 0.5 h at 50° C. as described in the general procedure 1.1. HPLC Rt: 4.045 min. 1H-NMR (CDCl3): δ 8.18 (s, 1H), 7.85 (s, 1H), 5.37 (s, 2H), 5.10 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H), 2.22 (s, 3H).

후처리

  1. customThe compound was obtained
  2. customfor 0.5 h
  3. customat 50° C.

출처 및 근거

ORD 기록
ord-1b1b0885a8d941f1970ae75b33c24c56
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138401B2

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