Cyclobutylamine → HCID 57633529, 화합물

HRID 722148노트

반응식

HRID 722148 반응식
[S:1]([O:5][C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8])([OH:4])(=[O:3])=O.[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1>C(Cl)Cl.CN(C=O)C>[OH:8][C:7]1[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=1[O:5][S:1](=[O:3])(=[O:4])[NH:17][CH:13]1[CH2:16][CH2:15][CH2:14]1

참가 물질

5

반응물 2

HCID 75645CyclobutylamineHCID 30838792-Hydroxyphenyl hydrogen sulfate

생성물 1

HCID 57633529HCID 57633529, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

Cyclobutyl-sulfamic acid 2-hydroxy-phenyl ester was prepared by adding a solution of catechol sulphate (1.32 g, 7.7 mmol) in DCM (2 ml) to a stirred solution of cyclobutylamine (600 μl, 7.0 mmol) and TEA (1.07 ml, 7.7 mmol) in DMF at 0° C., and stirring for 3 hours at this temperature. The mixture was quenched with 1M HCl (50 ml) and extracted with diethyl ether. The organic extract was washed with water, brine, dried and concentrated to dryness. Quantitative yield.

후처리

  1. customThe mixture was quenched with 1M HCl (50 ml)
  2. extractionextracted with diethyl ether
  3. extractionThe organic extract
  4. washwas washed with water, brine
  5. customdried
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-cc413cc509c3422c8cffb0a66d4b3418
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138400B2

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