Thionyl Chloride → 3-Quinuclidinecarbonyl chloride Hydrochloride

HRID 722169

반응식

HRID 722169 반응식
[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[CH:4]([C:10]([OH:12])=O)[CH2:3]2.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1>[ClH:15].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[CH:4]([C:10]([Cl:1])=[O:12])[CH2:3]2

참가 물질

4

반응물 2

HCID 24386Thionyl Chloride2회HCID 126734361-Azabicyclo(2.2.2)octane-3-carboxylic acid hydrochloride

생성물 1

HCID 126734373-Quinuclidinecarbonyl chloride Hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

500 mg (2.61 mmol) of 3-quinuclidinecarboxylic acid hydrochloride (Orlek et al., J. Med. Chem. 1991, 34, 2726) are boiled together with 1.9 ml (26.09 mmol) of thionyl choride under reflux for 2 h. The reaction mixture is freed of thionyl chloride under reduced pressure. 20 ml portions of toluene are twice added and evaporated to dryness. The product obtained in this way is reacted further without further purification.

후처리

  1. temperatureunder reflux for 2 h
  2. customevaporated to dryness
  3. customThe product obtained in this way
  4. customis reacted further without further purification

출처 및 근거

ORD 기록
ord-da64b4506e7f45239d54214f6ee18580
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138410B2

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