Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole → 2-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3-fluoro-4-nitrophenyl)-1H-1,2,4-triazole | HCID 21883919 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-4-(1,2,4-triazol-1-yl)phenylamine | HCID 21883866 | — |
반응 단계
Hydrogen was introduced under atmospheric pressure into the mixture consisting of 260 mg of 1-(3-fluoro-4-nitrophenyl)-1H-[1,2,4]triazole, 30 mg of Pd/C and 30 ml of tetrahydrofuran until the theoretical amount had been taken up. After filtering off the catalyst with suction and concentrating the mixture under reduced pressure, the remaining oily residue was purified by column chromatography (solvent: 98:2 dichloromethane:methanol; silica gel).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07138414B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-762ba5ff5a6e4357a88537fe8142c26b |
| 출처 메모 | uspto-grants-2006_11 |