5-Methyl-2-(3-methyl-4-nitrophenyl)-1,2-dihydro-3H-pyrazol-3-one → 2-(4-Amino-3-methylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

HRID 722225노트

반응식

HRID 722225 반응식
[H][H].[CH3:3][C:4]1[NH:8][N:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([CH3:18])[CH:10]=2)[C:6](=[O:19])[CH:5]=1>[Pd].O1CCCC1>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([N:7]2[C:6](=[O:19])[CH:5]=[C:4]([CH3:3])[NH:8]2)=[CH:10][C:11]=1[CH3:18]

참가 물질

5

반응물 2

HCID 218838945-Methyl-2-(3-methyl-4-nitrophenyl)-1,2-dihydro-3H-pyrazol-3-oneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 218838762-(4-Amino-3-methylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Hydrogen was introduced under atmospheric pressure into the mixture of 350 mg of 5-methyl-2-(3-methyl-4-nitrophenyl)-1,2-dihydropyrazol-3-one, 70 mg of Pd/C and 50 ml of tetrahydrofuran until the theoretical uptake. Afterwards, the catalyst was filtered off with suction and the mixture was concentrated to dryness under reduced pressure and the residue was stirred in t-butyl methyl ether. The solid was filtered off with suction and dried under reduced pressure.

후처리

  1. filtrationAfterwards, the catalyst was filtered off with suction
  2. concentrationthe mixture was concentrated to dryness under reduced pressure
  3. filtrationThe solid was filtered off with suction
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-92788c62c87442159c8485c81f7ecd9b
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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