N-methyl-2-pyrrolidone → 1-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

HRID 722232노트

반응식

HRID 722232 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[NH:12]1[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]1.CN1C(=O)CCC1>O>[F:8][C:5]1[CH:6]=[CH:7][C:2]([N:12]2[CH2:20][CH2:19][CH2:18][CH:14]([C:15]([NH2:17])=[O:16])[CH2:13]2)=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1

참가 물질

5

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 677672,5-DifluoronitrobenzeneHCID 929803-Piperidinecarboxamide

생성물 1

HCID 218839121-(4-Fluoro-2-nitrophenyl)piperidine-3-carboxamide

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

The mixture consisting of 1.62 g of 2,5-difluoronitrobenzene, 1.9 g of nipecotamide and 10 ml of NMP was heated with stirring to 80° C. for 2 hours. After the mixture had been allowed to cool, 30 ml of water were added and the mixture was stirred at RT for 30 minutes. The precipitated solid was filtered off with suction and dried under reduced pressure.

후처리

  1. temperaturewas heated
  2. temperatureto cool
  3. stirringthe mixture was stirred at RT for 30 minutes
  4. filtrationThe precipitated solid was filtered off with suction
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-74461f99bffd49d08ace61153edfed1a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138414B2

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