Water → HCID 21883959, 화합물

HRID 722260노트

반응식

HRID 722260 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][CH:14]1[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]1[NH:23][C:24](=[O:27])[CH2:25]I)=[O:12])=[CH:5]2.C(=O)([O-])[O-:29].[Na+].[Na+].O>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][CH:14]1[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]1[NH:23][C:24](=[O:27])[CH2:25][OH:29])=[O:12])=[CH:5]2

참가 물질

5

반응물 3

HCID 962Water2회HCID 10340Sodium CarbonateHCID 21883979HCID 21883979, 화합물

생성물 1

HCID 21883959HCID 21883959, 화합물수율 86.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

5-Chloro-N-{1-[(iodoacetyl)amino]-2,3-dihydro-1H-inden-2-yl}-1H-indole-2-carboxamide (Method 7a; 60 mg, 0.12 mmol) and sodium carbonate (100 mg) were dissolved in 1:1 dioxane:water (5 mL) and heated to reflux for 20 hours. The reaction was cooled, water (10 mL) added, filtered and the filter cake washed with water (3×1 mL) and dried to give the title compound (40 mg, 85%) as a white powder.

후처리

  1. temperatureto reflux for 20 hours
  2. temperatureThe reaction was cooled
  3. filtrationfiltered
  4. washthe filter cake washed with water (3×1 mL)
  5. customdried

출처 및 근거

ORD 기록
ord-20739e7b3170467b8b9e03123cc3cdee
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138415B2

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