Salicylaldehyde → 5-Chloro-4-fluoro-2-hydroxybenzaldehyde

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].C(=O)C1[C:12](=CC=CC=1)[OH:13]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:12]=[O:13])[C:5]([OH:8])=[CH:4][C:3]=1[F:9]

참가 물질

반응물 2

HCID 6998Salicylaldehyde

HCID 27245234-Chloro-3-fluorophenol2회

생성물 1

HCID 71721325-Chloro-4-fluoro-2-hydroxybenzaldehyde

실험 절차

4-Chloro-3-fluorophenol (Avocado product #16029) was converted to the salicylaldehyde via a method similar to that described in Example 2, Step 1: mp 102.7–103.7° C. 1H NMR (CDCl3/300 MHz) 11.22 (d, 1H, J=1.6 Hz), 9.80 (s, 1H), 7.63 (d, 1H, J=7.9 Hz), 6.77 (d, 1H, J=10.3 Hz). 19F NMR (CDCl3/282 MHz) −100.3 (t).

출처 및 근거

ORD 기록: ord-6f62b5e537614914bbaea54a82615372
출처 데이터셋: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07138411B2

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