2-Aminophenol → 5-(2-Benzoxazolyl)-2-methylbenzenamine

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[NH2:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:13](O)=O>>[NH2:9][C:10]1[CH:11]=[C:12]([C:13]2[O:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:16]=[CH:17][C:18]=1[CH3:19]

참가 물질

반응물 2

HCID 58012-Aminophenol

HCID 755683-Amino-4-methylbenzoic acid

생성물 1

HCID 7210305-(2-Benzoxazolyl)-2-methylbenzenamine

실험 절차

Prepared by the method of Example 1a), from 2-aminophenol (720 mg, 7.0 mmol) and 3-amino-4-methylbenzoic acid (1.00 g, 7.0 mmol) the subtitle compound was obtained, 942 mg (57%). 1H NMR (DMSO) δ 7.67(m, 2H), 7.42(s, 1H), 7.31(m, 2H), 7.24(d, 1H), 7.07(d, 1H), 2.43(s, 3H). MS 225 m/z (M+H)+.

출처 및 근거

ORD 기록: ord-ae53d6a7b0bb49bc96594932e9c42089
출처 데이터셋: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07138425B2

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