4-Fluorophenylboronic acid → HCID 21884522, 화합물

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2].[F:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:26]4[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=4)=[CH:17][C:15]=3[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])([O-:3])=[O:2]

참가 물질

반응물 2

HCID 2856454-Fluorophenylboronic acid

HCID 218843422-(3-Nitro-4-methoxyphenyl)-5-bromobenzoxazole

생성물 1

HCID 21884522HCID 21884522, 화합물

실험 절차

Prepared by the method of Example 15d), from 2-(3-nitro-4-methoxyphenyl)-5-bromobenzoxazole (200 mg, 0.57 mmol) and 4-fluorophenylboronic acid (120 mg, 0.86 mmol) the subtitle compound was obtained, (135 mg, 65%). 1H NMR (DMSO) δ 8.64(d, 1H), 8.45(dd, 1H), 8.05(d, 1H), 7.87(d, 2H), 7.78(dd, 1H), 7.72(dd, 1H), 7.62(d, 2H), 7.33(t, 1H), 4.08(s, 3H).

출처 및 근거

ORD 기록: ord-72994dc741b145fda4ab38ba75d1cd1a
출처 데이터셋: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07138425B2

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