Trimellitic anhydride → 2-[4-Allyloxy-3-(5-phenylbenzoxazol-2-yl)phenyl]-1,3-dioxo-2,3-dihydro-1h-isoindole-5-carboxylic acid
반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH2:24][CH:25]=[CH2:26])=[C:6]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:13][C:11]=3[N:12]=2)[CH:7]=1.[CH:27]1[C:32]([C:33]([OH:35])=[O:34])=[CH:31][C:30]2[C:36]([O:38][C:39](=O)[C:29]=2[CH:28]=1)=[O:37]>>[CH2:24]([O:23][C:5]1[CH:4]=[CH:3][C:2]([N:1]2[C:36](=[O:37])[C:30]3[C:29](=[CH:28][CH:27]=[C:32]([C:33]([OH:35])=[O:34])[CH:31]=3)[C:39]2=[O:38])=[CH:7][C:6]=1[C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:13][C:11]=2[N:12]=1)[CH:25]=[CH2:26]참가 물질
3
실험 절차
Prepared by the method of Example 1b), from 2-(5-amino-2-allyloxyphenyl)-5-phenylbenzoxazole (190 mg, 0.55 mmol) and 1,2,4-benzenetricarboxylic anhydride (106 mg, 0.55 mmol) the title compound was obtained (102 mg, 36%). 1H NMR (DMSO) δ 8.57(m, 1H), 8.35(dd, 1H), 8.37(s, 1H), 8.13(d, 1H), 7.94(m, 3H), 7.77(d, 1H), 7.63(m, 3H), 7.35(m, 4H), 6.04(m, 1H), 5.49(dd, 1H), 5.33(dd, 1H), 4.77(d, 2H). MS 517 m/z (M+H)+.
출처 및 근거
- ORD 기록
- ord-88420af8b1874ef4abbea5ef2b9af9be
- 출처 데이터셋
- uspto-grants-2006_11
- 특허 번호
- US07138425B2
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