Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid monohydrate → 2-(3-Nitro-6-fluorophenyl)-5-fluorobenzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | N-(2-Hydroxy-5-fluorophenyl)-2-fluoro-5-nitrobenzamide | HCID 21884478 | — |
| 생성물 | 2-(3-Nitro-6-fluorophenyl)-5-fluorobenzoxazole | HCID 21884339 | — |
반응 단계
Prepared by the method of Example 15b), from N-(2-hydroxy-5-fluorophenyl)-2-fluoro-5-nitrobenzamide (676 mg, 2.3 mmol) and p-toluenesulfonic acid monohydrate (961 g, 5.1 mmol) the subtitle compound was obtained (318 mg, 50%). 1H NMR (DMSO) δ 8.94(m, 1H), 8.54(m, 1H), 7.95(m, 1H), 7.81(m, 2H), 7.41(m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07138425B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-89f4689cd2754a0db483bb81c2967789 |
| 출처 메모 | uspto-grants-2006_11 |