1-Bromoheptadecane → (2S,3R)-2-(N,N-Dibenzylamino)-3-eicosanol

HRID 722808

반응식

HRID 722808 반응식
[CH2:1]([N:8]([C@@H:16]([CH3:19])[CH:17]=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>>[CH2:9]([N:8]([C@H:16]([C@H:17]([OH:18])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH3:21])[CH3:19])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 190221-BromoheptadecaneHCID 11107860(S)-2-Dibenzylamino-propionaldehyde

생성물 1

HCID 10185068(2S,3R)-2-(N,N-Dibenzylamino)-3-eicosanol

실험 절차

According to the method of Example 26, from aldehyde 4 (410 mg, 1.62 mmol) and 1-bromoheptadecane (2.07 g, 6.47 mmol), alcohol 44 was obtained as a colorless oil (427 mg, 53% yield).

출처 및 근거

ORD 기록
ord-5c931f77dba94d13b323b4b905646b87
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138547B2

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