1-Bromohexadecane → (3S,4R)-3-(N,N-Dibenzylamino)-4-eicosanol

HRID 722813

반응식

HRID 722813 반응식
[CH2:1]([N:8]([C@@H:16]([CH2:19][CH3:20])[CH:17]=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>>[CH2:9]([N:8]([C@H:16]([C@H:17]([OH:18])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH3:22])[CH2:19][CH3:20])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 82131-BromohexadecaneHCID 57433110(S)-2-(dibenzylamino)butanal

생성물 1

HCID 58743374(3S,4R)-3-(N,N-Dibenzylamino)-4-eicosanol

실험 절차

According to the method of Example 26, from aldehyde 6 (600 mg, 2.24 mmol) and 1-bromohexadecane (1.37 mL, 4.49 mmol), alcohol 59 was obtained as a colorless oil (775 mg, 70% yield).

출처 및 근거

ORD 기록
ord-916b8aa9851e4adcbc98737686908853
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138547B2

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