1-Bromopentadecane → (4S,5R)4-(N,N-Dibenzylamino)-5-eicosanol

HRID 722815

반응식

[CH2:1]([N:8]([C@@H:16]([CH2:19][CH2:20][CH3:21])[CH:17]=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>>[CH2:9]([N:8]([C@H:16]([C@H:17]([OH:18])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH3:23])[CH2:19][CH2:20][CH3:21])[CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 123941-Bromopentadecane

HCID 44223341(S)-2-(dibenzylamino)pentanal

생성물 1

HCID 58743391(4S,5R)4-(N,N-Dibenzylamino)-5-eicosanol

실험 절차

According to the method of Example 26, from aldehyde 11 (123 mg, 0.44 mmol) and 1-bromopentadecane (318 mg, 1.09 mmol), alcohol 65 was obtained as a colorless oil (161 mg, 75% yield).

출처 및 근거

ORD 기록: ord-7d382c90ffc5416ab555e245fdc9281c
출처 데이터셋: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07138547B2

연결된 노트

불러오는 중…