Water → N-(4-bromo-2-ethylphenyl)acetamide
반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH3:10])[CH:3]=1.C(N(CC)CC)C.[C:18](Cl)(=[O:20])[CH3:19].O>ClCCl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:18](=[O:20])[CH3:19])=[C:4]([CH2:9][CH3:10])[CH:3]=1참가 물질
6
실험 절차
To a solution of 4-bromo-2-ethylaniline (50 g, 0.25 mol) in dichloromethane (250 ml) is added triethylamine (63.24 g, 0.62 mol) and the mixture is stirred at room temperature for 30 minutes. The reaction mixture is cooled to 0° C. and acetyl chloride (39.25 g, 0.5 mol) is added dropwise. The reaction mixture is stirred at 25-30° C. for 60 minutes, then poured into water, and the two phases separated. The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered and the filtrate is evaporated under reduced pressure to yield N-(4-bromo-2-ethylphenyl)acetamide (40 g).
후처리
- temperatureThe reaction mixture is cooled to 0° C.
- stirringThe reaction mixture is stirred at 25-30° C. for 60 minutes
- customthe two phases separated
- washThe organic phase is washed with water
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- customthe filtrate is evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-e2a9b5b2b9234194b9d11bee1e03abde
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08828908B2
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