1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one → HCID 21887034, 화합물

HRID 722976노트

반응식

HRID 722976 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH3:11])[C:3]1=[O:12].[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][CH2:21][N:22]([CH3:31])[CH:23]([CH3:30])[CH2:24][CH2:25][CH2:26][C:27](O)=[O:28]>>[ClH:13].[CH3:11][N:4]1[C:5]2[CH:10]=[CH:9][C:8]([C:27](=[O:28])[CH2:26][CH2:25][CH2:24][CH:23]([N:22]([CH2:21][CH2:20][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[Cl:13])[CH3:31])[CH3:30])=[CH:7][C:6]=2[N:2]([CH3:1])[C:3]1=[O:12]

참가 물질

3

반응물 2

HCID 2315531,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-oneHCID 21887510HCID 21887510, 화합물

생성물 1

HCID 21887034HCID 21887034, 화합물수율 112.2%

실험 절차

Using 484 mg (3 mmol) of 1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one and 850 mg (3.3 mmol) of (±)-5-[[2-(2-chlorophenyl)ethyl](methyl)amino]hexanoic acid obtained in Reference Example 202 according to the same method as that of Example, a free base compound of the title compound (860 mg) was obtained as a pale yellow oil.

후처리

  1. customobtained in Reference Example 202 according to the same method as that of Example

출처 및 근거

ORD 기록
ord-308e51e8cc9347ab821f0e356454ea3a
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138533B2

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