Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl propionate → 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl propionate | HCID 11124 | — |
| 반응물 | 5-(4-Benzyloxyphenyl)-[1,3,4]oxathiazol-2-one | HCID 59549525 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 3-(4-Benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester | HCID 66617751 | — |
반응 단계
5-(4-benzyloxy-phenyl)-[1,3,4]oxathiazol-2-one (0.4 g, 1.4 mmol) and 0.23 ml of methyl propionate were dissolved in 10 ml of chlorobenzene and then refluxed overnight. The solvent was distilled off under reduced pressure and the obtained crude compound was purified by silica gel column chromatography to obtain 3-(4-benzyloxy-phenyl)-isothiazol-5-carboxylic acid methyl ester as a desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828992B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bae299a0dd6140dd87b26a0cdc892800 |
| 출처 메모 | uspto-grants-2014_09 |