참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Potassium Nitrate | HCID 24434 | — |
| 반응물 | 4-Bromothiophene-2-carbaldehyde | HCID 87792 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 4-Bromo-5-nitrothiophene-2-carbaldehyde | HCID 21886281 | 98.6% |
반응 단계
A solution of potassium nitrate (110 g, 1.09 mol) in H2SO4 (550 mL, conc.) was added to a solution of 4-bromo-thiophene-2-carbaldehyde (207.6 g, 1.08 mol) in H2SO4 (1.1 L, conc.) at CH2Cl2 (5 mL, anhydrous) at 0° C. over a 45 minute period. The reaction mixture was stirred 0° C. for 2 hrs, then stirred overnight at rt. The reaction mixture was poured over ice, filtered, and washed with water and hexanes. The yellow solid was dried overnight to afford the title compound (251.4 g, 98.6%). 1H-NMR (DMSO-d6): δ 9.90 (s, 1H), 8.56 (s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07138530B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_11 |
|---|
| ORD ID | ord-d103f6c77f19491694048527fd202014 |
|---|
| 출처 메모 | uspto-grants-2006_11 |
|---|
