Chlorosulfonic acid → 4-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

HRID 723268노트

반응식

HRID 723268 반응식
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11](N)(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15].[Cl:16]S(O)(=O)=O>>[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([Cl:16])(=[O:13])=[O:12])=[CH:4][C:3]=1[Br:15]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 218864374-Amino-3-bromo-5-nitrobenzenesulfonamide

생성물 1

HCID 218861144-Amino-3-bromo-5-nitrobenzenesulfonyl chloride

실험 절차

4-Amino-3-bromo-5-nitrobenzenesulfonamide ((U.S. Pat. No. 3,987,199) 1 g, 3.17 mmol) was heated at 95° C. for 3 h in chlorosulfonic acid (10 mL). The solution was cooled then poured onto ice and then filtered. The solid was redissolved in DCM and dried over sodium sulfate. Removal of the solvent yielded the product (960 mg) which was used without further purification.

후처리

  1. temperatureThe solution was cooled
  2. additionthen poured onto ice
  3. filtrationfiltered
  4. dissolutionThe solid was redissolved in DCM
  5. dry with materialdried over sodium sulfate
  6. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-d7643db29aef469cab93861f74cd4494
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138530B2

반응 노트

불러오는 중…