Water → 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

HRID 723312노트

반응식

HRID 723312 반응식
N1C=CC=CC=1.[NH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15].[Br:16][C:17]([CH3:22])([CH3:21])[C:18](Br)=[O:19].O>C(Cl)Cl>[Br:16][C:17]([CH3:22])([CH3:21])[C:18]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[C:9]=1[OH:15])=[O:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 886852-Bromo-2-methylpropionyl bromideHCID 155315062-Amino-6-bromophenol

생성물 1

HCID 218735182-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Pyridine (1.8 ml, 22.3 mmol) was added to a solution of 2-Amino-6-bromo-phenol (4.198 g, 22.3 mmol) in dry CH2Cl2 (200 ml). The mixture was cooled in ice and then a solution of 2-bromo-2-methyl-propionylbromide (2.8 ml, 22.6 mmol) was added slowly. The mixture was stirred at the room temperature for an hour and was poured into CH2Cl2 and water. The organic layer was washed with water, dried and concentrated in vacuo to yield crude 2-bromo-N-(3-bromo-2-hydroxy-phenyl)-2-methyl-propionamide, which was used directly in step 2.

후처리

  1. temperatureThe mixture was cooled in ice
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-da887553a4e74faebce16e987dc52703
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141562B2

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