1-[4-(2-Dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one → 1-[3-Amino-4-(2-dimethylaminoethylamino)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

HRID 723330노트

반응식

HRID 723330 반응식
[CH3:1][N:2]([CH3:34])[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])=[CH:8][C:7]=1[N+:31]([O-])=O>ClCCl.C(O)(=O)C.[Zn]>[NH2:31][C:7]1[CH:8]=[C:9]([N:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])[CH:10]=[CH:11][C:6]=1[NH:5][CH2:4][CH2:3][N:2]([CH3:34])[CH3:1]

참가 물질

5

반응물 1

HCID 218733991-[4-(2-Dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

생성물 1

HCID 218733231-[3-Amino-4-(2-dimethylaminoethylamino)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 176Acetic Acid용매HCID 6344Dichloromethane용매

실험 절차

Zinc dust (250 mg) was added to a solution of 1-[4-(2-dimethylamino-ethylamino)-3-nitrophenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one (50 mg) in dichloromethane (10 ml) and glacial acetic acid (1 ml). After 10 minutes, solids were removed by filtration and the filtrate was washed with saturated sodium carbonate solution. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 429.53 (C25H27N5O2); MS (ESI): 430 ([M+H]+), was obtained in this way.

후처리

  1. customsolids were removed by filtration
  2. washthe filtrate was washed with saturated sodium carbonate solution
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customMS (ESI): 430 ([M+H]+), was obtained in this way

출처 및 근거

ORD 기록
ord-adca3358e96b49a3acfa98a756ae33aa
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141561B2

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