홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Hydroxide → HCID 21873464, 화합물

HRID 723353
노트
인쇄 미리보기

반응식

HRID 723353 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1F)([O-:3])=[O:2].[CH3:11][N:12]([CH3:35])[CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=3)[C:23]2=[O:34])=[CH:18][CH:17]=1.[OH-].[K+]>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:35])[CH2:13][CH2:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH:26]=[CH:25][N:24]([C:27]3[CH:28]=[CH:29][C:30]([O:33][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[N+:1]([O-:3])=[O:2])=[CH:31][CH:32]=3)[C:23]2=[O:34])=[CH:20][CH:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 738951-Fluoro-2-nitrobenzeneHCID 21873309HCID 21873309, 화합물

생성물 1

HCID 21873464HCID 21873464, 화합물

시약·촉매·용매 2

HCID 21218Trioctylmethylammonium chloride촉매HCID 1140Toluene용매

실험 절차

2-Nitrofluorobenzene (0.14 g) was added to a mixture of 1-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-hydroxyphenyl)-1,3-dihydroimidazol-2-one (0.34 g), Aliquat® 336 (0.04 g, tricaprylylmethylammonium chloride), potassium hydroxide (0.077 g) and toluene (10 mL). The mixture was heated under reflux for 3 hours. After cooling, the reaction solution was washed with water, dried and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 460.49 (C25H24N4O5); MS (ESI): 461 ([M+H]+), was obtained as hydrotrifluoroacetate in this way.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling
  4. washthe reaction solution was washed with water
  5. customdried
  6. concentrationconcentrated
  7. customThe residue was purified by preparative HPLC
  8. customMS (ESI): 461 ([M+H]+), was obtained as hydrotrifluoroacetate in this way

출처 및 근거

ORD 기록
ord-1fd1d3dfba3943b8a732453c75c32217
출처 데이터셋
uspto-grants-2006_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07141561B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트