Pyridine → 4-Methyl-N-(oxo-lambda~4~-sulfanylidene)benzamide

HRID 72343

반응식

HRID 72343 반응식
[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([C:7]([NH2:9])=[O:8])=[CH:3][CH:2]=1.N1C=CC=CC=1.[S:17](Cl)(Cl)=[O:18]>CCOCC>[S:17](=[N:9][C:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:10])=[CH:2][CH:3]=1)=[O:8])=[O:18]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 692744-Methylbenzamide

생성물 1

HCID 133013154-Methyl-N-(oxo-lambda~4~-sulfanylidene)benzamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

p-Toluamide (76 g) and pyridine (95.5 ml) were initially charged in dry ether (600 ml) and, while cooling with ice, thionyl chloride (70.2 g) in ether (200 ml) was added dropwise. The mixture was stirred at room temperature overnight. With exclusion of moisture, the pyridine hydrochloride was then filtered off and washed with ether (100 ml). The solution was concentrated under reduced pressure and the residue (83.5 g) was used without further purification.

후처리

  1. additionwas added dropwise
  2. filtrationWith exclusion of moisture, the pyridine hydrochloride was then filtered off
  3. washwashed with ether (100 ml)
  4. concentrationThe solution was concentrated under reduced pressure
  5. customthe residue (83.5 g) was used without further purification

출처 및 근거

ORD 기록
ord-40888b505acd4683b7f2770905b7cad1
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828995B2

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