Ammonia → 3,6-Dichloropyridazin-4-amine

HRID 723531노트

반응식

HRID 723531 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[NH3:10]>>[NH2:10][C:7]1[CH:6]=[C:5]([Cl:9])[N:4]=[N:3][C:2]=1[Cl:1]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 951233,4,6-Trichloropyridazine

생성물 1

HCID 2984983,6-Dichloropyridazin-4-amine

실험 절차

A suspension of 3,4,6-trichloropyridazine (prepared by the method of B. Kasnar et al, Nucleosides and Nucleotides, 1994, 13, 459) (10.0 g) in conc. aqueous ammonia (1 L) was heated at 75° C. for 16 h. The mixture was concentrated to a small volume and extracted several times with ethyl acetate. The extracts were washed with brine, dried and evaporated. The crude product was recrystallised from ethyl acetate to give the product (5.03 g).

후처리

  1. customprepared by the method of B
  2. concentrationThe mixture was concentrated to a small volume
  3. extractionextracted several times with ethyl acetate
  4. washThe extracts were washed with brine
  5. customdried
  6. customevaporated
  7. customThe crude product was recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-cb541affb9eb4221b14af8d75c7103b1
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141564B2

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