4-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene → 4-(4-Dimethylaminosulfonylbenzyl)-phenylamine

HRID 723567노트

반응식

HRID 723567 반응식
[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4]>C(OCC)(=O)C.[Pd]>[CH3:22][N:2]([CH3:1])[S:3]([C:6]1[CH:21]=[CH:20][C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:5]

참가 물질

4

반응물 1

HCID 218769584-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene

생성물 1

HCID 218770384-(4-Dimethylaminosulfonylbenzyl)-phenylamine수율 102.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

4-(4-Dimethylaminosulfonylbenzyl)-nitrobenzene (311 mg) was dissolved in ethyl acetate and hydrogenated at 40 psi using a 10% palladium on carbon catalyst for 2 hours. The mixture was filtered, and solvents evaporated to give 4-(4-dimethylaminosulfonylbenzyl)-phenylamine as a white solid (288 mg, 99%).

후처리

  1. customfor 2 hours
  2. filtrationThe mixture was filtered
  3. customsolvents evaporated

출처 및 근거

ORD 기록
ord-438bf96cd14649fa939d8b78022f87da
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141584B2

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