4-Toluenesulfonyl chloride → HCID 131725182, 화합물

HRID 723642

반응식

HRID 723642 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:12][C:13]1[O:17][C:16]([CH2:18][CH2:19][OH:20])=[CH:15][CH:14]=1>N1C=CC=CC=1>[CH3:12][C:13]1[O:17][C:16]([CH2:18][CH2:19][OH:20])=[CH:15][CH:14]=1.[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O-:10])(=[O:17])=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 110623902-(5-Methylfuran-2-yl)ethan-1-ol

생성물 1

HCID 131725182HCID 131725182, 화합물수율 152.9%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-Methylbenzenesulfonyl chloride (907 mg, 4,76 mmol) was added to a solution of compound 21A (500 mg, 3.96 mmol) in 6 mL of dry pyridine. The reaction was stirred at room temperature for 4 h and then quenched with ice. The reaction mixture was extracted with CH2Cl2 and the combined organic layers were washed with saturated aqueous sodium bicarbonate and water, dried and concentrated under reduced pressure to give 900 mg (81%) of compound 24A as a yellow oil.

후처리

  1. customquenched with ice
  2. extractionThe reaction mixture was extracted with CH2Cl2
  3. washthe combined organic layers were washed with saturated aqueous sodium bicarbonate and water
  4. customdried
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0d2c06d1412547b89eed8534ad717d46
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141578B2

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