Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide

HRID 723708

반응식

HRID 723708 반응식
[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[OH:9]O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[N+:5]([O-:9])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 237193-Methoxypyridine

생성물 1

HCID 139850Pyridine, 3-methoxy-, 1-oxide수율 100%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
70 °C

실험 절차

3-Methoxypyridine (20.08g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.

후처리

  1. customThe cooled reaction mixture
  2. concentrationwas concentrated
  3. dissolutionthe residue dissolved in CH2Cl2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4810d2db956f4b21951da1528e907e51
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141578B2

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