Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide
반응식
[CH3:1][O:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1.[OH:9]O>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[N+:5]([O-:9])[CH:6]=[CH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
3-Methoxypyridine (20.08g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.
후처리
- customThe cooled reaction mixture
- concentrationwas concentrated
- dissolutionthe residue dissolved in CH2Cl2
- filtrationThe mixture was filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-4810d2db956f4b21951da1528e907e51
- 출처 데이터셋
- uspto-grants-2006_11
- 특허 번호
- US07141578B2
반응 노트
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