HCID 15219197, 화합물 → 2-amino-3-fluorophenol

HRID 723921노트

반응식

HRID 723921 반응식
C([O:8][C:9]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:10]=1[NH2:11])C1C=CC=CC=1>[Pd].CO>[NH2:11][C:10]1[C:12]([F:16])=[CH:13][CH:14]=[CH:15][C:9]=1[OH:8]

참가 물질

4

반응물 1

HCID 15219197HCID 15219197, 화합물

생성물 1

HCID 27827782-amino-3-fluorophenol수율 99.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-(Benzyloxy)-6-fluoroaniline (Step 2, 5.00 g, 0.0230 mol) and 10% palladium on carbon (0.5 g) in methanol (100 ml) are stirred under a hydrogen atmosphere (balloon) for 2 h. The catalyst is removed by filtration through a pad of celite and the filtrate concentrated to give pure product as a tan solid (2.9 g, 99%); mp 125–6° C.

후처리

  1. customThe catalyst is removed by filtration through a pad of celite
  2. concentrationthe filtrate concentrated

출처 및 근거

ORD 기록
ord-705804d338de446ab6250f03dc945655
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141588B2

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