Ammonium Chloride → 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

HRID 723935노트

반응식

HRID 723935 반응식
[F:1][C:2]1[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=[C:4]([N+:15]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 68487872HCID 68487872, 화합물

생성물 1

HCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

Prepared from 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 0.87 g, 3.64 mmol), ammonium chloride (1.95 g, 36.4 mmol) and iron powder (0.81 g, 14.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.77 g, 99%).

출처 및 근거

ORD 기록
ord-72e5a3046f50441e9d2e41abaf387a75
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141588B2

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