N-[(2-fluoro-5-nitrophenyl)carbamothioyl]benzamide → 5-Nitro-1,3-benzothiazol-2-amine
반응식
C[O-].[Na+].C([NH:12][C:13]([NH:15][C:16]1[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[CH:19]=[CH:18][C:17]=1F)=[S:14])(=O)C1C=CC=CC=1>CO>[N+:22]([C:20]1[CH:19]=[CH:18][C:17]2[S:14][C:13]([NH2:12])=[N:15][C:16]=2[CH:21]=1)([O-:24])=[O:23]참가 물질
4
실험 절차
To a solution of methanol (1.6 L) was added sodium methoxide (8.64 g). While stirring, 1-benzoyl-3-(2-fluoro-5-nitro-phenyl)-thiourea (16 g) was added as a solid and the mixture stirred at room temperature for 17 hours. After this time, the reaction mixture was cooled in an ice bath and then filtered. The precipitate was washed with water (7.10 g, 86%). 1H-NMR δ: 8.05 (d, 1H, J=2.2 Hz), 7.97 (brs, 2H), 7.93 (s, 1H), 7.90 (d, 1H, J=2.2 Hz); MS (ESI) 195.8 (M+1, 100%).
후처리
- stirringthe mixture stirred at room temperature for 17 hours
- temperatureAfter this time, the reaction mixture was cooled in an ice bath
- filtrationfiltered
- washThe precipitate was washed with water (7.10 g, 86%)
출처 및 근거
- ORD 기록
- ord-2bb3380b827d4311a12cc1309e178602
- 출처 데이터셋
- uspto-grants-2006_11
- 특허 번호
- US07141595B2
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