1-(2-Amino-benzothiazol-5-yl)-3-benzoyl-thiourea → N-(2-Amino-1,3-benzothiazol-5-yl)thiourea

HRID 723953노트

반응식

HRID 723953 반응식
C[O-].[Na+].[NH2:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([NH:17]C(=O)C3C=CC=CC=3)=[S:16])=[CH:10][C:8]=2[N:9]=1>CO>[NH2:4][C:5]1[S:6][C:7]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([NH2:17])=[S:16])=[CH:10][C:8]=2[N:9]=1

참가 물질

4

반응물 2

HCID 100421591-(2-Amino-benzothiazol-5-yl)-3-benzoyl-thioureaHCID 10942334Sodium Methoxide

생성물 1

HCID 10263051N-(2-Amino-1,3-benzothiazol-5-yl)thiourea

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of anhydrous methanol (213 mL) was added sodium methoxide (1.15 g) and 1-(2-amino-benzothiazol-5-yl)-3-benzoyl-thiourea (Example 17, 3.5 g). The resulting mixture was stirred at room temperature for 3 hours. The mixture was concentrated and the residue was poured into water (300 mL). The mixture was extracted using ethyl acetate (3×200 mL). The combined organic fractions were dried over magnesium sulfate, filtered and concentrated (1.61 g, 67%). 1H-NMR (DMSO d6) δ: 9.64 (s, 1H), 760–7.37 (m, 6H), 6.96 (d, 1H, J=8.3 Hz); MS (ESI) 224.8 (M+1, 100%).

후처리

  1. concentrationThe mixture was concentrated
  2. additionthe residue was poured into water (300 mL)
  3. extractionThe mixture was extracted
  4. dry with materialThe combined organic fractions were dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated (1.61 g, 67%)

출처 및 근거

ORD 기록
ord-2d147e4a4f77402cb0359c7476e5289c
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141595B2

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