3-Fluorophenol → 1-Benzhydryl-3-(3-fluorophenoxy)azetidine

HRID 72401

반응식

HRID 72401 반응식
CS([O:5][CH:6]1[CH2:9][N:8]([CH:10]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7]1)(=O)=O.[F:23][C:24]1[CH:25]=[C:26](O)[CH:27]=[CH:28][CH:29]=1>>[CH:10]([N:8]1[CH2:9][CH:6]([O:5][C:28]2[CH:27]=[CH:26][CH:25]=[C:24]([F:23])[CH:29]=2)[CH2:7]1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 97433-FluorophenolHCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate

생성물 1

HCID 197996211-Benzhydryl-3-(3-fluorophenoxy)azetidine수율 80.9%

실험 절차

The title compound (D22) (1.93 g) was prepared according to the experimental procedure described in Description 21 starting from 1-benzhydrylazetidin-3-yl methanesulfonate (D19) (2.5 g, 7.87 mmol) and 3-fluorophenol (0.642 ml, 7.16 mmol).

출처 및 근거

ORD 기록
ord-83dabc3e49b94d36991f1f54a4471d05
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

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