3-Oxo-azetidine-1-carboxylic acid tert-butyl ester → Tert-butyl 3-((2-methyl-4-(trifluoromethyl)phenyl)amino)azetidine-1-carboxylate

반응식

[C:1]([N:8]1[CH2:11][C:10](=O)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=1[CH3:24]>>[CH3:24][C:15]1[CH:16]=[C:17]([C:20]([F:21])([F:22])[F:23])[CH:18]=[CH:19][C:14]=1[NH:13][CH:10]1[CH2:11][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

참가 물질

반응물 2

HCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl ester

HCID 137504374-Amino-3-methylbenzotrifluoride

생성물 1

HCID 67958091Tert-butyl 3-((2-methyl-4-(trifluoromethyl)phenyl)amino)azetidine-1-carboxylate수율 21.4%

실험 절차

The title compound (D32) (330 mg) was prepared according to the experimental procedure described in Description 30 starting from 1-Boc-3-azetidinone (800 mg, 4.67 mmol) and 4-Amino-3-methylbenzotrifluoride (818.4 mg, 4.67 mmol).

출처 및 근거

ORD 기록: ord-dbd1b969ca3146dabb36fd51d7ef2a38
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828987B2

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