3-(Trifluoromethyl)phenol → Tert-butyl 3-(3-(trifluoromethyl)phenoxy)pyrrolidine-1-carboxylate

HRID 72412노트

반응식

HRID 72412 반응식
[C:1]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[F:14][C:15]([F:24])([F:23])[C:16]1[CH:17]=[C:18](O)[CH:19]=[CH:20][CH:21]=1>>[F:14][C:15]([F:24])([F:23])[C:16]1[CH:21]=[C:20]([CH:19]=[CH:18][CH:17]=1)[O:13][CH:10]1[CH2:11][CH2:12][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

참가 물질

3

반응물 2

HCID 73763-(Trifluoromethyl)phenolHCID 44169391-Boc-3-pyrrolidinol

생성물 1

HCID 24902563Tert-butyl 3-(3-(trifluoromethyl)phenoxy)pyrrolidine-1-carboxylate수율 84.8%

실험 절차

The title compound (D35) (1.5 g) was prepared according to the experimental procedure described in Description 34 starting from 1-Boc-3-pyrrolidinol (1 g, 5.34 mmol) and 3-(Trifluoromethyl)phenol (0.640 ml, 5.34 mmol)

출처 및 근거

ORD 기록
ord-bd8f73af06f749e598053bb4ebb3924a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

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