HCID 21876061, 화합물 → HCID 21876466, 화합물

HRID 724198노트

반응식

HRID 724198 반응식
[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:25])([F:24])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([N:30]=[N+]=[N-])([CH3:29])[CH3:28])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]>[Pd].CC([O-])=O.CC([O-])=O.[Pb+2].CO>[C:1]([O:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17]3[CH:18]=[C:19]([Cl:26])[C:20]([C:22]([F:24])([F:25])[F:23])=[CH:21][C:16]=3[N:15]=[C:14]2[C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:11][CH:12]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 21876061HCID 21876061, 화합물

생성물 1

HCID 21876466HCID 21876466, 화합물수율 98.2%

시약·촉매·용매 2

HCID 131709914Lindlars catalyst촉매HCID 887Methanol용매

실험 절차

A mixture of 2-{4-[2-(1-azido-1-methylethyl)-6-chloro-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl acetate (step 2, 133 mg, 0.28 mmol) and Lindlar catalyst (13 mg) in methanol (5 ml) was stirred under H2 atmosphere at room temperature for 2.5 h. The catalyst was removed by filtration through a pad of celite and the filtrates were concentrated to give the title compound as yellow oil (121 mg, 98%).

후처리

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationthe filtrates were concentrated

출처 및 근거

ORD 기록
ord-5e98be99ddf04736a9e9455e1ebad9c0
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141580B2

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