3-Fluorophenol → (R)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate

반응식

[OH:1][C@H:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[F:14][C:15]1[CH:16]=[C:17](O)[CH:18]=[CH:19][CH:20]=1>>[F:14][C:15]1[CH:20]=[C:19]([CH:18]=[CH:17][CH:16]=1)[O:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1

참가 물질

반응물 2

HCID 97433-Fluorophenol

HCID 854055tert-Butyl (3S)-3-hydroxypyrrolidine-1-carboxylate

생성물 1

HCID 67958316(R)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate수율 98.1%

실험 절차

The title compound (D47) (294.6 mg) was prepared according to the experimental procedure described in Description 40 starting from (S)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (200 mg, 1.068 mmol, available at Aldrich#634786) and 3-Fluorophenol (0.096 ml, 1.068 mmol).

출처 및 근거

ORD 기록: ord-432db41749aa47bd8c0968977931ddc4
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828987B2

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