Trimethylsilyldiazomethane → Methyl 2-chloro-5-fluoronicotinate

HRID 72434노트

반응식

HRID 72434 반응식
[Cl:1][C:2]1[N:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12][Si](C=[N+]=[N-])(C)C>>[Cl:1][C:2]1[N:10]=[CH:9][C:8]([F:11])=[CH:7][C:3]=1[C:4]([O:6][CH3:12])=[O:5]

참가 물질

3

반응물 2

HCID 167693TrimethylsilyldiazomethaneHCID 114352432-Chloro-5-fluoronicotinic acid

생성물 1

HCID 24229209Methyl 2-chloro-5-fluoronicotinate수율 83.4%

실험 절차

The title compound (D69) (0022/105/1) (1.8 g) was prepared according to the experimental procedure described in Description 66 starting from 2-Chloro-5-fluoronicotinic acid (2 g, 11.39 mmol) and trimethylsilyldiazomethane (2M solution in diethyl ether) (17 ml, 34.18 mmol)

출처 및 근거

ORD 기록
ord-3f6d446cdb1b4a22937cf879919aa8b4
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

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