Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| 반응물 | tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate | HCID 65813955 | — |
| 생성물 | Methyl 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinate | HCID 67958200 | 60.3% |
반응 단계
The title compound (D81) (0021/074/1) (75.9 mg) was prepared according to the experimental procedure described in Description 80 starting from tert-butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate (D29) (100 mg, 0.374 mmol) and methyl 2,5-dichloronicotinate (77.32 mg, 0.374 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d3bb85cc8ad3477ba58a356b34090d63 |
| 출처 메모 | uspto-grants-2014_09 |