Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(2-fluoro-5-nitrophenyl)benzamide → N-(5-Amino-2-fluorophenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(2-fluoro-5-nitrophenyl)benzamide | HCID 675819 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 생성물 | N-(5-Amino-2-fluorophenyl)benzamide | HCID 11148928 | 91% |
반응 단계
A mixture of N-(2-fluoro-5-nitro-phenyl)-benzamide (4.86 g, 18.7 mmol) and 10% Pd/C (486 mg) in a 1:1 mixture of THF-MeOH (80 ml) was hydrogenated at 23° C. After 2.5 h the reaction mixture was filtered through celite and concentrated to give N-(5-Amino-2-fluoro-phenyl)-benzamide (3.92 g, 91%). MS (ESI+) [M+H]/z Calc'd 231. found 231.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07141587B2 |
| 출처 데이터셋 | uspto-grants-2006_11 |
| ORD ID | ord-4cf1559bac90484eb09770de2041e2c8 |
| 출처 메모 | uspto-grants-2006_11 |