Methyl 2,5-Dichloronicotinate → HCID 67958251, 화합물

반응식

Cl[C:2]1[N:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[F:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][CH:21]2[CH2:24][NH:23][CH2:22]2)=[CH:16][CH:15]=1>>[Cl:12][C:9]1[CH:10]=[N:11][C:2]([N:23]2[CH2:24][CH:21]([NH:20][C:17]3[CH:16]=[CH:15][C:14]([F:13])=[CH:19][CH:18]=3)[CH2:22]2)=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5]

참가 물질

반응물 2

HCID 2764318Methyl 2,5-Dichloronicotinate

HCID 58975143N-(4-fluorophenyl)azetidin-3-amine

생성물 1

HCID 67958251HCID 67958251, 화합물수율 78.4%

실험 절차

The title compound (D84) (79 mg) was prepared according to the experimental procedure described in Description 62 starting from Methyl 2,5-dichloronicotinate (62.06 mg, 0.3 mmol) and N-(4-fluorophenyl)azetidin-3-amine (D54) (60 mg, 0.361 mmol).

출처 및 근거

ORD 기록: ord-00d6f91e2a6140f998827f8ce73772d8
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08828987B2

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