2-(Tributylstannyl)-1,3-thiazole → 2-(3-Fluoro-4-hydroxyphenyl)-4-thiazol-2-yl-quinolin-6-ol

HRID 7245

반응식

HRID 7245 반응식
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([F:20])[CH:14]=2)[CH:3]=1.C([Sn](CCCC)(CCCC)[C:26]1[S:27][CH:28]=[CH:29][N:30]=1)CCC>>[F:20][C:15]1[CH:14]=[C:13]([C:4]2[CH:3]=[C:2]([C:26]3[S:27][CH:28]=[CH:29][N:30]=3)[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=3)[N:5]=2)[CH:18]=[CH:17][C:16]=1[OH:19]

참가 물질

3

반응물 2

HCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 1354779434-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol

생성물 1

HCID 1354891292-(3-Fluoro-4-hydroxyphenyl)-4-thiazol-2-yl-quinolin-6-ol수율 56%

실험 절차

This compound was prepared from 6b and 2-tributylstannylthiazole according to method J. Yellow powder; Yield: 56%; mp>280° C. (dec.); 1H-NMR (400 MHz, DMSO-d6) δ 7.10 (t, J=8.8 Hz, 1H), 7.38 (dd, J=9.1, 2.7 Hz, 1H), 7.95–8.00 (m, 2H), 8.07–8.12 (m, 3H), 8.21 (m, 2H), 10.18 (s, 1H), 10.26 (s, 1H); MS (ESI) m/z 337 ([M−H]−), 339 ([M+H]+); Anal. Calcd for C18H11FN2O2S: C: 63.90, H: 3.28, N: 8.28. Found: C: 62.6, H: 3.43, N: 7.59.

출처 및 근거

ORD 기록
ord-51161c16317b4c838a8ed98ea6f53449
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084276B2

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