{2-[(6-Nitro-1H-indole-2-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester → {2-[(6-Amino-1H-indole-2-carbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester
반응식
[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[C:17]([N+:22]([O-])=O)[CH:16]=2)=[O:12])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:25])[NH:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[C:17]([NH2:22])[CH:16]=2)=[O:12])([CH3:4])([CH3:2])[CH3:3]참가 물질
4
실험 절차
Compound 35 (0.184 g, 0.528 mmol) was dissolved in 15 ml of MeOH and hydrogenated over 5% Pd/C under 40 psi of H2 for 30 min. TLC showed that reaction was completed. After filtration through celite, the filtrate was evaporated and the residue was dried under high vacuum to give compound 36.