돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72460생성일: 2026년 10월 25일

3-(Trifluoromethoxy)phenol → 5-Chloro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid

https://huagongshe.com/reaction/72460

반응식

참여 물질

역할이름HCID투입량
반응물3-(Trifluoromethoxy)phenolHCID 2733261—
반응물Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinateHCID 86697874—
생성물5-Chloro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acidHCID 67958627101.5%

반응 단계

The title compound (D107) (112 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 3-(trifluoromethoxy)phenol (0.036 ml, 0.284 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08828987B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-ff1ecc0189de419cb78dc21dec2cc2d4
출처 메모uspto-grants-2014_09