3,4-Difluorophenol → 5-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid

HRID 72462

반응식

HRID 72462 반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:15][CH:14]([O:16]S(C)(=O)=O)[CH2:13]2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[F:21][C:22]1[CH:23]=[C:24](O)[CH:25]=[CH:26][C:27]=1[F:28]>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([N:12]2[CH2:15][CH:14]([O:16][C:25]3[CH:24]=[CH:23][C:22]([F:21])=[C:27]([F:28])[CH:26]=3)[CH2:13]2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

참가 물질

3

반응물 2

HCID 759273,4-DifluorophenolHCID 86697874Methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate

생성물 1

HCID 679585205-Chloro-2-(3-(3,4-difluorophenoxy)azetidin-1-yl)nicotinic acid수율 89.9%

실험 절차

The title compound (D109) (87 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 5-chloro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D63) (100 mg, 0.311 mmol) and 3,4-Difluorophenol (36.87 mg, 0.284 mmol).

출처 및 근거

ORD 기록
ord-c5af9a5393f64c708a00179f31e6aee7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

연결된 노트

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